Set up TSM properly, learn it well and I can already see the power potential it has. Second is diversify your markets, learn other markets and the more you set up the more potential profit you have. Third is probably leveling alts so you have a wide range of professions ready to tackle any future opportunities for profit. Forth read patch notes religiously.
Professions skills are split between expansions now, you'll have a separate skill bar for each expansion. There are still 950 profession levels in total, just that there is no one single progress bar with 1 to 950 for it anymore. Instead, there are 8 separate progress bars. (The only exception is Archaeology, because it will still have a 1-950 progress bar)
Mythic+ rewards will also go up by 30 item levels; however, during the first week of Season 2, rewards from end-of-run chests will be capped at Mythic 6 quality (item level 385), and the chest you open next week will contain Season 1 rewards if you do a Mythic+ run this week. (So, for example, if you do a Mythic 10 during the final week of Season 1, you’ll get a Season 1 item level 380 piece and 60 Residuum from your first Season 2 chest.)