Set up TSM properly, learn it well and I can already see the power potential it has. Second is diversify your markets, learn other markets and the more you set up the more potential profit you have. Third is probably leveling alts so you have a wide range of professions ready to tackle any future opportunities for profit. Forth read patch notes religiously.
JC Panthers: Instead of breaking them all down like I did with the golem, I'll just note that currently on my server the Orb of Mystery and the Living Steel combined cost 36,000g. All of the panthers, except the Onyx, sell for 32,000g. A loss of 4,000g/unit, not including the gems. Once we factor those in, at a mean value of ~200g/unit, the loss per Panther jumps to 8,000g.
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If you're willing to dedicate, get tailoring for increased cloth drops, and look at group finder. Under custom search for "boe" and try to find and join a 2x4 farm group. It's basically just hours of leading npcs into a grinder for loot, but you'll make 20-40k an hour from cloth depending on server prices, and on average every 2-4 hrs you'll find a boe epic worth 80-250k, if luck permits.
All of my gold came from everyone buying stuff at a really marked up price for instance BS 2h mace if it proced epic i was making at least 125k per one and i was making batchs of 10 to 15 it was like 25k for blue and 125k+ for epics at the time. And i was buying the ore for like 16g to 40g a pop so huge profit. Im still trying to figure out what im gunna do now to rebuild it will be a slow process now.