After being deposed as Warchief of the Horde in Battle for Azeroth, Sylvanas Windrunner travels to Icecrown Citadel in the Scourge-infested wastes of Northrend, and confronts the reigning Lich King, Bolvar Fordragon. Taking the Lich King's Helm of Domination from him, she tears it in two, shattering the veil between realities and opening a portal to the Shadowlands, Azeroth's afterlife. The Shadowlands have become warped in function during recent times. The Maw, a place in the afterlife reserved for the most sinful souls, is now absorbing all souls.
In the opening cinematic, Sylvanas shatters the Helm of Dominion, breaching the veil between the material realm and the Shadowlands, an ancient dimension where the dead coalesces for judgment. Sylvanas' actions have upset the natural balance between life and death, and it's on players to enter the Shadowlands itself and repair the cycle before it is too late.
The Shadowlands can be seen as a shadowy version of the physical world, and can be routinely visited as a spirit when player characters die. Governed by the Covenants, the four ruling realms of the Shadowlands are Bastion, Ardenweald, Revendreth and Maldraxxus (although countless others exist), which serve as the main setting of World of Warcraft's eighth expansion.