Once you reach an Alchemy skill of 475, you may begin a quest to learn one of three specializations: Potions,Elixirs or Transmutations. Being specialized gives you a chance to create an extra 1 to 4 (for a total 5) items while crafting in the field you have selected. For example, a Master of Potions may be able to craft more than one [Super Mana Potion] for the same material cost as one.
Do quests and complete the story of your first chosen area before returning to your capital to scrap all of the equipment items you acquired. You should be around Level 113 by the time you complete your first area. Before selecting your second zone, head to your faction hub ship to acquire your introductory quests to the mission table and your champions. Complete this introduction and then pick up the quest to establish your first foothold in enemy territory.
Eventually, the Alliance finishes its preparations and launches an attack on the Zadalari capital of Dazar'zalor, their goal being to sever the budding alliance between the Zandalari and the Horde by dismantling the Golden Fleet and capturing King Rastakhan. Despite Anduin and Jaina's desire to capture him alive, Rastakhan is overwhelmed by the power of his pact with the Loa Bwonsamdi, and the Alliance champions are forced to slay him. Enraged by Rastakhan's death, Horde champions launch a vicious counterattack on the withdrawing Alliance forces, which ends with both Jaina and High Tinkerer Mettatorque gravely wounded. As the Alliance leadership debates their next move, Sylvanas, infuriated by the Horde's defeat, resurrects Jaina's long dead brother Derek Proudmoore as a Forsaken, an act that horrifies the surviving Horde leaders, with the intent to use him as a sleeper agent to destroy the Proudmoore family from within.
I tell you my experience. I'm leveling a priest that it's 60 now and since I have also done some instances (and I have full heirloom set with 20% experience gain bonuses) and been very ahead of the guide, I skipped some zones since they were grey quest for me, well it was a real mess. Missing quests because I didn't to the previous to enable the following. Going in a zone then realizing that I couldn't do that quest because I didn't do the starting quest chain, very unconmfortable. In short what I suggest you it's not to skip areas, or make really sure that you do all the quests required (at least) and check carefully the previous zone you'll going to skip to make sure that you won't have problems with struggling finding where to start the quest chain to sync with the guide section.
Prepare the Horde for war by recruiting the ancient empire of Zandalar. In this troll-dominated territory, ancient evil waits to be unleashed on the world as you battle crazed blood-troll worshippers, gargantuan dinosaurs, and titan constructs. Discover Zuldazar, the oldest city in Azeroth; unveil the bleak swamps of Nazmir; and traverse the deadly deserts of Vol'dun.
Elixirs serve the same purpose as Flasks, but the buff expires if you die. You'll only use these between 1-70, generally speaking, until you can start buying Flasks which persist through death. Try not to die, and carry extras just in case. If you can't find an Elixir with the stat you want, look under scrolls, since they count as battle or guardian buffs as well.
That lack of storytelling agency may soon change with Patch 8.1, Tides of Vengeance, which is coming to Battle for Azeroth soon. While there are plenty of fun gameplay changes that should make the expansion better, one of the most interesting additions is that of choice. In an upcoming quest, players will be able to choose whether they want to support Saurfang or Sylvanas — essentially honor or evil — in the struggle for Horde warchief.